![]() In conventional nuclear architecture, heterochromatin is enriched at the nuclear periphery and around nucleoli. The distribution and configuration of heterochromatin and euchromatin, as well as protein-mediated specific interactions among genomic elements determine the spatial architecture of chromatin. For instance, it has been observed that the volume of cell nucleus is a main determinant of the overall landscape of chromatin folding. The position, structure and configuration of heterochromatin and euchromatin regions are closely related to gene expression. Ĭhromatin fibers can be divided into transcriptionally inactive and condensed region, called heterochromatin, and transcriptionally active and more accessible region, called euchromatin. In the nuclei of eukaryotes, DNA molecule wraps around histones and form nucleosomes, which is further packaged into chromatin fiber and integrated to form chromosomes.
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